![]() ![]() Effect of fiberoptic collimation technique on 808 nm wavelength laser stimulation of cochlear neurons. Speech recognition in noise as a function of the number of spectral channels: Comparison of acoustic hearing and cochlear implants. Cross-modal plasticity and cochlear implants. Restoration of auditory evoked responses by human ES-cell-derived otic progenitors. Generation of hair cells by stepwise differentiation of embryonic stem cells. Mechanosensitive hair cell-like cells from embryonic and induced pluripotent stem cells. Application of targeting-optimized chronos for stimulation of the auditory pathway. Cochlear implants: System design, integration, and evaluation. The role of electroneural versus electrophonic stimulation on psychoacoustic electric-acoustic masking in cochlear implant users with residual hearing. Better speech recognition with cochlear implants. Mechano-gated ion channels in sensory systems. Mechanosensory hair cells express two molecularly distinct mechanotransduction channels. Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation. ![]() The precise temporal pattern of prehearing spontaneous activity is necessary for tonotopic map refinement. Mechanically gated ion channels in mammalian hair cells. Hair cell mechanotransduction regulates spontaneous activity and spiral ganglion subtype specification in the auditory system. This study thus reports a new method of highly spatially selective hearing enhancement without introducing any exogeneous gene, which has potential applications for treatment of hearing disorders as well as several other areas of neuroscience. In addition, measurement of auditory brainstem response (ABR) in guinea pigs treated with THM indicated a ~ 10 dB increase in hearing sensitivity. Using single-cell electrophysiology, guinea pig audiometry, and molecular dynamics simulations, we show that THM can reversibly increase mechano-electrical transducer currents (∼ 50% higher) and voltage-gated K + currents in cochlear hair cells through collective resonance of −C=O groups. Here, in this work, we describe terahertz wave modulation, a new and minimally invasive technology that can enhance hearing perception in animals by reversible modulation of currents in cochlear hair cells. Moreover, cochlear implants have disadvantages, such as crosstalk derived from the currents that spread into non-target tissue between the electrodes. However, the improvements to hearing perception are variable and limited among healthy subjects. Currently, the most effective clinical treatment for patients with sensorineural deafness is to implant an artificial electronic cochlea. Hearing impairment is a common disease affecting a substantial proportion of the global population. ![]()
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